연구분야
삼채 뿌리 메탄올 추출물이 LPS가 유도된 RAW264.7 세포에 대한 항염증 효과 ? 연구노트 ?
- 작성일2017.05.15 00:00
- 분류
- 조회수1,813
- 링크https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324216/
- 저널명한국식품영양과학회지
- 저자김창현,김현주,이미애,김태운,장자영
- 구분
- 유형
제목
삼채 뿌리 메탄올 추출물이 LPS가 유도된 RAW264.7 세포에 대한 항염증 효과 ? 연구노트
요약
Allium hookeri, a member of the onion family, has long been mainly cultivated for food and medicinal use in Southeast Asia countries owing to its various biological properties. However, no studies of the anti-inflammatory effects of A. hookeri extracts have been conducted to date. Therefore, this study was investigated the potential of the methanol extract of A. hookeri to suppress the inflammation in lipopolysaccharide (LPS)-induced mouse macrophage RAW264.7 cells. This study was performed on macrophage cells that were pretreated with 0~500 μg/mL of methanol extract of A. hookeri root prior to LPS treatment. Treatment with methanol extract of A. hookeri root significantly inhibited LPS-induced nitric oxide formation in dose-dependent manner. Treatment of A. hookeri root also significantly decreased LPS-induced TNF-α and IL-6 production. The results of this study provide new evidence of the anti-inflammatory properties of A. hookeri and indicate that it may have a potential therapeutic use for the prevention and treatment of macrophage derived chronic immune diseases.
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